Description
Buy toseina Codeine phosphate hemihydrate
Buy toseina Codeine phosphate hemihydrate made to Spain used by itself or combined in a syrup with other drugs and is used as a cough suppressant in adults aged 18 and above.
Codeine Phosphate is the phosphate salt of codeine, a naturally occurring phenanthrene alkaloid and opioid agonist with analgesic, antidiarrheal and antitussive activities.
See also
Codeine mimics the actions of endogenous opioids by binding to the opioid receptors at many sites within the central nervous system (CNS). Stimulation of mu-subtype opioid receptors results in a decrease in the release of nociceptive neurotransmitters such as substance P, GABA, dopamine, acetylcholine and noradrenaline; in addition, the codeine metabolite morphine induces opening of G-protein-coupled inwardly rectifying potassium (GIRK) channels and blocks the opening of N-type voltage-gated calcium channels, resulting in hyperpolarization and reduced neuronal excitability. Stimulation of gut mu-subtype opioid receptors results in a reduction in intestinal motility and delayed intestinal transit times. Antitussive activity is mediated through codeine’s action on the cough center in the medulla.
Medical categories:
Human: Analgesics (opioid) Antitussives Cough and cold preparations Opiate agonists
For oral administration.
Adult:
One 5ml spoonful four times daily.
Elderly:
Should be used with caution; a reduced dose can be recommended by a doctor.
Paediatric population
Codeine should not be used for the treatment of children under the age of 18 years.
Alverline –
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